Department of Experimental Physics 5 (Biophysics)

University of Würzburg, Germany
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NMR Imaging of the Heart

(Mycardial Function and Microcirulation)

within Sonderforschungsbereich 355 "pathophysiology of the heart insufficiency"

The working group under the direction of Prof. Dr. Dr. med. Wolfgang R. Bauer and Prof. Dr. Peter M. Jakob/Prof. Dr. Axel Haase exists since 1993 and concerns themselves with the development and use of methods for the quantification of the myocardial function and microcirculation both at the isolated heart and in vivo.

Members of the working group are

Index

Cardiac Imaging

One of the main topics at the Chair of Biophysics in Würzburg is the developement of new strategies for cardiac perfusion quantification as well as lesion mapping. We apply these new techniques to recent patient studies and validate them with standard techniques including X-ray angiography and SPECT. These studies include HCM, DCM and a variety of cardiovascular diseases.

Further information about small animals see here or contact  Dr. Gert Klug

Clinical Studies

A variety of clinical studies are performed in collaboration with companies and the University hospital of Würzburg. These include all standard clinical cardiac examinations as well as specialized study protocols designed for specific questions or rare clinical cases.

Contact:

 Dr. Peter Nordbeck

 Dr. Florian Fidler

Methods 

Methods already applied:

NMR Systems - Hardware 

In the Department of Experimental Physics V (Biophysics) we have a 7 Tesla Bruker Biospec horizontal system (300 mc/s, 20 cm bore) for in vivo investigations. For the measurements of the isolated heart a Bruker Avance 500 vertical system (11.75 Tesla, 500 mc/s, 8.9 cm bore, gradient strength up to 0,66 T/m) is used. Since August 2001 we have a new 17T Bruker Avance 750 WB both for the in vivo measurements of mice and isolated hearts.

Furthermore there are two whole body scanners, each having a fieldstrength of 1.5 T (Vision, Avanto)

Further informations about Magnets

Projects: 

Our working group concerns itself with the development of NMR methods for the quantification of the microcirculation. The combination of the already established NMR imaging methods allows us to determine geometrical-mechanical parameters of the heart function e.g. ventricle volumes and myocardial masses and parameters of microcirculation. This enables us to pursue the remodeling process after myocardial infarction. Thus, in the future we intend to apply these techniques in clinically relevant animal models of the heart insufficiency and ventricular dysfunction. In addition, the measurement of further parameters of the myocardial microcirculation is developed further.

Another field of activity is to improve safety for patients with implanted medical devices in MRI. This issue is becoming increasingly important because the number of patients with such devices is rapidly growing. The goal of the current project "Entwicklung MR-kompatibler Schrittmacherelektroden" is to develop MRI-compatible pacemaker-leads to minimize the risk of side effects for patients with pacemakers in MRI. This project is a cooperation with the company BIOTRONIK and supported by the Bavarian Research Foundation (BFS).

Cooperation

Cooperation exists to the laboratory for Myocardial Energetics at the John Radcliffe Hospital in Oxford and the working group of the Department of Biophysics and Medical Radiation Physics of the Institute for Radiology and Pathophysiology at the DKFZ in Heidelberg Prof. Dr. Lothar Schad. Further close contacts exist to the Department of Biotechnology .

Press comments

Mainpost, 09-13-2005

Technology Review October 2004

Physikalisch-Technische Bundesanstalt, 04-02-2003

Helmholtzpreis 2003

Innovationsreport, 06-25-2003

Mainpost, 03-21-2001

Main Echo 03-22-2001

Links

 Arbeitssicherheit und Tierschutz

 

Publications 

 2007
  • D. Farina, O. Skipa, C. Kaltwasser, O. Dössel, W.R. Bauer "Optimization-Based Reconstruction of Depolarization of the Heart" IEEE: in press (2007)
  • M. Nahrendorf, W.R. Bauer "Recent advances in small animal cardiac magnetic resonance imaging" Current Cardiology Reviews, in press (2007)
  • C. H. Ziener, T. Kampf, W. R. Bauer, P. M. Jakob, S. Glutsch, F. Bechstedt "Quantum beats in semiconductors" Int J of Modern Physics B 21 (8-9): 1621-1625 (2007)
 2006
  • W.R. Bauer, W. Nadler "Molecular transport through channels and pores" PNAS 103 (31): 11446-11451 (2006)
  • K.H. Hiller, C. Waller, M. Nahrendorf, W.R. Bauer, P.M. Jakob "Assessment of cardiovascular apoptosis in the isolated rat heart using magnetic resonance molecular imaging" Mol Imag 5(2): 115-121 (2006)
  • M. Nahrendorf, JUG Streif, K.H. Hiller, K. Hu, P. Nordbeck, O. Ritter, D.E. Sosnovik, L. Bauer, S. Neubauer, P.M. Jakob, G. Ertl, M. Spindler, W.R. Bauer "Multimodal functional cardiac MR imaging in creatine kinase deficient mice reveals subtile abnormalities in myocardial perfusion and mechanics" Am J Physiol Heart Circ Physiol 290: H2516-H2521 (2006)
  • M. Nahrendorf, W.R. Bauer "Cardiac MR techniques applied to small rodents" In Vivo MR Techn. in Drug Disc. and Dev. (Ed. Nicolau Beckmann). Taylor & Francis, New York, pp. 315-327 (2006)
  • M. Nahrendorf, K. Hu, S. Frantz, F.A. Jaffer, C.-H. Tung, K.-H. Hiller, S. Voll;, P. Nordbeck, D. Sosnovik, S. Gattenlöhner, M. Novikov, G. Dickneite, G.L. Reed, P. Jakob, A. Rosenzweig, W.R. Bauer, R. Weissleder, G. Ertl "Factor XIII Deficiency Causes Cardiac Rupture, Impairs Wound Healing, and Aggravates Cardiac Remodeling in Mice With Myocardial Infarction" Circulation 113: 1196-1202 (2006)
  • O. Ritter, M.L. Koller, B. Fey, B. Seidel, A. Krein, H. Langenfeld, W.R. Bauer "Progression of heart failure in right univentricular pacing compared to biventricular pacing" Int J Cardiol 28 110(3): 359-65 (2006)
  • O. Ritter, W.R. Bauer "Use of “IEGM Online” in ICD patients - early detection of inappropriate classified ventricular tachycardia via Home Monitoring" Clin Res Cardiol 95: 1-5 (2006)
  • F. Weidemann, C. Wacker, A. Rauch, W.R. Bauer, B. Bijnens, G.R. Sutherland, G. Ertl, W. Voelker, F. Fidler, J.M. Strotmann "Sequential changes of myocardial function during acute myocardial infarction, in the early and chronic phase after coronary intervention described by ultrasonic strain rate imaging" J Am Soc Echocardiography 19:839-847 (2006)
 2005
  • W.R. Bauer "Measurements in the magnetic field" German Research (Magazine of the DFG) 2: 15-16 (2005)
  • W.R. Bauer "Messung der Mikrozirkulationsparameter Intrakapillarvolumen, Kapillarrekrutierung und Durchblutung im Herzmuskel mittels NMR-Tomographie" Wissenschaft.Spitzenforschung in der Herzkreislaufmedizin (Sept.): 10-21 (2005)
  • W.R. Bauer, W. Nadler "Stationary flow, first passage times and macroscopic Fick's first diffusion law: application to flow enhancement by particle trapping" J of Chem Phys 122: 244904 -1 - 244904 -13 (2005)
  • H.B. Hillenbrand, L.C. Becker, R. Kharrazian, K. Hu, C.E. Rochitte, R.J. Kim, E.L. Chen, G. Ertl, R.H. Hruban, J.A.C. Lima "23Na MRI combined with contrast-enhanced 1H MRI provides in vivo characterization of infarct healing" MRM 53: 843-850 (2005)
  • K.-H. Hiller, C. Faber, T. Neuberger, S. Köhler, A. Stroh, C. Zimmer, P. Jakob "Magnet-Resonanz-Tomographie: Möglichkeiten der molekularen Bildgebung" Z med Phys 15: 155-162 (2005)
  • M.L. Koller, S.K.G. Maier, A.R. Gelzer, W.R. Bauer, M. Meesmann, R.F. Gilmour "Altered dynamics of action potential restitution and alternans in humans with structural heart disease" Circulation 112: 1542-1548 (2005)
  • M. Nahrendorf, M. Spindler, K. Hu, L. Bauer, O. Ritter, P. Nordbeck, T. Quaschning, K.-H. Hiller, J. Wallis, G. Ertl, W.R. Bauer, S. Neubauer "Creatine kinase knockout mice show left ventricular hypertrophy and dilatation, but unaltered remodeling post-myocardial infarction" Cardiovas Res 65: 419-427 (2005)
  • JUG Streif, M. Nahrendorf, K.-H. Hiller, C. Waller, F. Wiesmann, E. Rommel, A. Haase, W.R. Bauer "In vivo assessment of absolute perfusion and intracapillary blood volume in the murine myocardium by spin labeling magnetic resonance imaging" MRM 53: 584-592 (2005)
  • C. Waller, K.-H. Hiller, T. Rüdiger, G. Kraus, C. Konietzko, N. Hardt, G. Ertl, W.R. Bauer "Noninvasive imaging of angiogenesis inhibition following nitric oxide synthase blockade in the ischemic rat heart in vivo" Microcirulation 12: 339-347 (2005)
  • C. Waller, T. Engelhorn, K.H. Hiller, G: Heusch, G. Ertl, W.R. Bauer, R. Schulz "Impaired Resting Perfusion in Viable Myocardium distal to Chronic Coronary Stenosis in Rats." Am J Physiol Heart Circ Physiol 288(6): H2588-2593 (2005)
 2004
  • R. Jerecic, M. Bock, S. Nielles-Vallespin, C. Wacker, W.R. Bauer, L.R. Schad "ECG-Gated 23Na-MRI of the Human Heart Using a 3D-Radial Projection Technique with Ultra Short Echo Times" MAGMA 16: 297-203 (2004)
  • M.L. Koller, S.K.G. Maier, W.R. Bauer, P. Schanzenbächer "Postcardiac injury syndrome following radiofrequency ablation of artrial flutter" Z Kardiol 93: 560-565 (2004)
  • M. Nahrendorf, K.-H. Hiller, K. Hu, V. Zeijlemaker, M. Griswold, W.R. Bauer "Pacing in High Field Cardiac Magnetic Resonance maging: Implantation of a Permanent Pacemaker into a Rat" PACE 27(5): 671­674 (2004)
  • J.J. Sandstede, H. Hillenbrand, M. Beer, T. Pabst, F. Butter, W. Machann, W.R. Bauer, D. Hahn, S. Neubauer "Time course of 23Na signal intensity after myocardial infarction in humans" MRM 52(3): 545-551 (2004)
 2003
  • G. Ertl, W. Bauer "Advances in managing heart failure and sudden cardiac death: reverse remodelling by drugs?" Europ Heart J Suppl. 5 (I): 44-53 (2003)
  • H.B. Hillenbrand, J. Sandstede, C. Lipke, H. Köstler, T. Pabst, E. Werner, G. Ertl, D. Hahn, W.R. Bauer "Detection of Myocardial Viability in Acute Infarction using Contrast-Enhanced 1H MRI" MAGMA 16(3): 129-34 (2003)
  • S. Köhler, K.-H. Hiller, C. Waller, P.M. Jakob, W.R. Bauer, A. Haase "Visualization of myocardial microstructure using high-resolution T2* imaging at high magnetic field" MRM 49 (2): 371-375 (2003)
  • S. Köhler, K.-H. Hiller, M. Griswold, W.R. Bauer, A. Haase, P.M. Jakob "NMR-microscopy with TrueFISP at 11.75 T" JMR 161: 252-257 (2003)
  • S. Köhler, K.-H. Hiller, C. Waller, W.R. Bauer, A. Haase, P.M. Jakob "Investigation of the Microstructure of the Isolated Rat Heart: A Comparison Between T2*- and Diffusion-Weighted MRI" MRM 50: 1144-1150 (2003)
  • S. Köhler, K.-H. Hiller, P.M. Jakob, W.R. Bauer, A. Haase "Time-resolved flow measurement in the isolated rat heart: Characterization of left coronary artery stenosis" MRM 50: 449-452 (2003)
  • M. Nahrendorf, K.H. Hiller, K. Hu, G. Ertl, A. Haase, W.R. Bauer "Cardiac magnetic resonance imaging in small animal models of human heart failure" Med Image Anal, 7(3): 369-375 (2003)
  • M. Nahrendorf, K. Hu, D. Fraccarollo, K.-H. Hiller, A. Haase, W.R. Bauer, G. Ertl "Time Course of Right Ventricular Remodeling in Rats With Experimental Myocardial Infarction" Am J Physiol Heart Circ Physiol 284 (1): H241-H248 (2003)
  • M. Nahrendorf, K.-H. Hiller, A. Greiser, S. Köhler, T. Neuberger, K. Hu, C. Waller, M. Albrecht, S. Neubauer; A. Haase, G. Ertl, W.R. Bauer "Chronic coronary artery stenosis induces impaired functionof remote myocardium: MRI and spectroscopy study in rat" Am J Physiol Heart Circ Physiol 285: H2712-H2721 (2003)
  • M. Nahrendorf, K.-H. Hiller, A. Greiser, S. Kohler, T. Neuberger, K. Hu, C. Waller, G. Ertl, A. Haase, W.R. Bauer "Magnetic resonance fusion imaging of chronic myocardial ischemia" Func Imag Mod Heart 2674: 272-277 (2003)
  • J.U.G. Streif, K.-H. Hiller, C. Waller, M. Nahrendorf, F. Wiesmann, W.F. Bauer, E. Rommel, A. Haase "In vivo assessment of absolute perfusion in the murine skeletal muscle with spin labeling MRI" J Magn Reson Imaging 17(1): 147-52 (2003)
  • JUG Streif, K.H. Hiller, C. Waller, M. Nahrendorf, F. Wiesmann, W.R. Bauer, E. Rommel, A. Haase "Reply" J Magn Reson Imag 18: 515-517 (2003)
  • C.M. Wacker, A.W. Hartlep, S. Pfleger, L.R. Schad, G. Ertl "Susceptibility-sensitive magnetic resonance imaging detects human myocardium supplied by a stenotic coronary artery without a contrast agent" J Am Coll Cardiol. 41(5): 834-40 (2003)
  • C.M. Wacker, W.R. Bauer "Neue Ansätze der Magnetresonanztomographie zur Beschreibung myokardialer Mikrozirkulationsparameter am Menschen" Herz 28: 74-81 (2003)
  • C. Waller, K.H. Hiller, M. Albrecht, K. Hu, M. Nahrendorf, S.Gattenlohner, A. Haase, G. Ertl, W.R. Bauer "Microvascular adaptation to coronary stenosis in the rat heart in vivo: a serial magnetic resonance imaging study" Microvasc Res, 66(3): 173-182 (2003)
 2002
  • W.R. Bauer, W. Nadler "Spin dephasing in the extended strong collision approximation" Phys Rev E 65: 066123-1 – 066123-15 (2002)
  • W.R. Bauer, G. Ertl "Rhythmusstörungen während der Remodelingphase nach Herzinfarkt" Herz 27: 740-749 (2002)
  • W.R. Bauer "Magnetresonanzangiographie und schnelles CT" Herzmedizin 19 (1): 12-20 (2002)
  • M. Nahrendorf, K. Hu, K.-H. Hiller, P. Galuppo, D. Fraccarollo, G. Schweizer,A. Haase, G. Ertl, W.R. Bauer, J. Bauersachs "Impact of Hydroxmethylglutaryl Coenzyme A Reductase Inhibition on Left Ventricular Remodeling After Myocardial Infarction" J Am Coll Cardiol, 40: 1695-1700 (2002)
  • M. Nahrendorf, K.-H. Hiller, D. Theisen, K. Hu, C. Waller, R. Kaiser, A. Haase, G. Ertl, R. Brinkmann, W. R. Bauer "Effect of Transmyocardial Laser Revascularization on Myocardial Perfusion and Left Ventricular Remodeling after Myocardial Infarction in Rats" Radiology 225: 487-493 (2002)
  • C.M. Wacker, F. Wiesmann, M. Bock, P. Jakob, J.J.W. Sandstede, A. Lehning, G. Ertl, L.R. Schad, A. Haase, W.R. Bauer "Determination of Regional Blood Volume and Intra-Extracapillary Water-Exchange in Human Myocardium Using Feruglose: First Clinical Results in Patients With Coronary Artery Disease" MRM 47: 1013-1016 (2002)
 2001
  • W. R. Bauer, K.-H. Hiller, P. Galuppo, S. Neubauer, J. Köpke, A. Haase, C. Waller, G. Ertl "Fast High-Resolution Magnetic Resonance Imaging Demonstrates Fractality of Myocardial Perfusion in Microscopic Dimensions" Circ Res Vol 88(3): 340-346 (2001)
  • P. Gaudron, I. Kugler, K. Hu, W.R. Bauer, C. Eilles, G. Ertl "Time course of cardiac structural, functional and electrical changes in asymptomatic patients post myocardial infarction, their interrelation and prognostic impact" J Am Coll Cardiol 18(1):33-40 (2001)
  • K.-H. Hiller, C. Waller, S. Voll. A. Haase, G. Ertl, W.R. Bauer "Combined High-Speed NMR Imaging of Perfusion and Microscopic Coronary Conductance Vessels in the Isolated Rat Heart" Microvascular Res. 62: 327-334 (2001)
  • M. Nahrendorf, K.-H. Hiller, K. Hu, C. Waller, F. Wiesmann, J. Ruff, G. Ertl, A. Haase, W.R. Bauer "In vivo assessment of rat hearts with and without myocardial infarction by cine NMR - comparison of the NMR method to invasive techniques and application to intervention studies" Lecture Notes in Computer Science 2230: 97-105 (2001)
  • M. Nahrendorf, F. Wiesmann, K.-H. Hiller K. Hu, C. Waller, J. Ruff, T.E. Lanz, S. Neubauer, A. Haase, G. Ertl, W.R. Bauer "Serial cine-magnetic resonance imaging of left ventricular remodeling after myocardial infarction in rats by" J Magn Reson Imag 14(5): 547-555 (2001)
  • J.J.W. Sandstede, T. Pabst, C. Wacker, F. Wiesmann, V. Hoffmann, M. Beer, W. Kenn, W.R. Bauer, D. Hahn "Breath-hold 3-D MR coronar angiography with a new intravascular contrast agent (feruglose)- first clinical expierences" JMRI 19: 201-205 (2001)
  • C. Waller, K.-H. Hiller, E. Kahler, K. Hu, M. Nahrendorf, S. Voll, A. Haase, G. Ertl, W.R. Bauer "Serial Magnetic Resonance Imaging of Microvascular Remodeling in the Infarcted Rat Heart" Circulation 103: 1564-1569 (2001)
  • C. Waller, K.H. Hiller, S. Voll, A. Haase, G. Ertl, W.R. Bauer "Myocardial perfusion imaging using a non-contrast agent NMR imaging technique" Int J Cardiovasc Imaging 17: 123-132 (2001)
  • F. Wiesmann, J. Ruff, S. Engelhardt, L. Hein, C. Dienesch, A. Leupold, R. Illinger, A. Frydrychowicz, K.-H. Hiller, E. Rommel, A. Haase, M.J. Lohse, S. Neubauer "Dobutamine stress magnetic resonance microimaging in mice: Acute changes of cardiac and function in normal and failing murine hearts" Circ Res 88: 563-569 (2001)
 2000
  • M. Nahrendorf, F. Wiesmann, K.-H. Hiller, H. Han, K. Hu, C. Waller, J. Ruff, A. Haase, G. Ertl, W.R. Bauer "In vivo Assessment of Cardiac Remodeling after Myocardial Infarction in Rats by Cine-Magnetic Resonance Imaging" Cardiov Magn Reson 2: 171-180 (2000)
  • J. Schneider, E. Fekete, A. Weisser, S. Neubauer, A. Haase, M. von Kienlin "Reduced 1H-NMR Visibility of Creatine in Isolated Rat Hearts" MRM 43(4): 497-502 (2000)
  • C. Waller, E. Kahler, K.-H. Hiller, K. Hu, M. Nahrendorf, S. Voll, A. Haase, G. Ertl, W.R. Bauer "Myocardial Perfusion and Intracapillary Blood Volume in Rats at Rest and Coronary Dilation: MR Imaging in vivo with Use of a Spin-Labeling Technique" Radiology 215(1): 189-197 (2000)
  • C. Weidensteiner, T. Lanz, M. Horn, S. Neubauer, A. Haase, M. von Kienlin "Three-Dimensional 13C-Spectroscopic Imaging in the Isolated Infarcted Rat Heart" J Magn Reson 143: 17-23 (2000)
  • F. Wiesmann, J. Ruff, K.-H. Hiller, E. Rommel, A. Haase, S. Neubauer "Developmental changes of cardiac function and mass assessed with MRI in neonatal, juvenile, and adult mice" Am J Physiol Heart Circ Physiol 278(2): H652-H657 (2000)
 1999
  • W.R. Bauer, W. Nadler, M. Bock, L.R. Schad, C. Wacker, A. Hartlep, G. Ertl "Theory of coherent and incoherent nuclear spin dephasing in the heart" Phys Rev Letters 83(20): 4215-4218 (1999)
  • W.R. Bauer, W. Nadler, M. Bock, L.R. Schad, C. Wacker, A. Hartlep, G. Ertl "The relationship between T2* and T2: A theoretical approach for the vasculature in myocardium" MRM 42: 1004-1010 (1999)
  • W.R. Bauer, W: Nadler, M. Bock, L.R. Schad, C.M. Wacker, A.W. Hartlep, G. Ertl "Theory of the BOLD effect in the capillary region: an analytical approach for the determination of T2* in the capillary network of myocardium" MRM 41: 51-62 (1999)
  • E. Kahler, C. Waller, E. Rommel, V. Belle, K.-H. Hiller, S. Voll, W.R. Bauer, A. Haase "Perfusion-corrected Mapping of Cardiac Regional Blood Volume in Rats in vivo" Magn Res Med 42: 500-506 (1999)
  • C.M. Wacker, M. Bock, A.W. Hartlep, W.R. Bauer, G. van Kaick, S. Pfleger, G. Ertl, L.R. Schad "BOLD MRI in 10 patients with coronary artery disease: evidence for imaging of capillary recruitment in myocardium supplied by a stenotic artery" MAGMA 8: 48-54 (1999)
  • C.M. Wacker, M. Bock, A.W. Hartlep, G. Beck, G. van Kaick, G. Ertl, W.R. Bauer, L.R. Schad "Changes in myocardial oxygenation and perfusion under pharmacological stress with dipyridamole: assessment using using T2* and T1" MRM 41: 686-695 (1999)
 1998
  • W. Bauer, C. Waller, E. Kahler, K.-H. Hiller K. Hu, A. Haase, G. Ertl "Myocardial Perfusion and Capillary Blood Volume During Left Ventricular Remodelling" MAGMA 6: 148-149 (1998)
  • V. Belle, E. Kahler, C. Waller, E. Rommel, S. Voll, K.-H. Hiller, W.R. Bauer, A. Haase "In vivo Quantitative Mapping of Cardiac Perfusion in Rats Using a Non Invasive MR Spin-labeling Method" J Magn Res Imaging 8: 1240-1245 (1998)
  • M. de Groot, B. Illing, M. Horn, B. Urban, A. Haase, K. Schnackerz, S. Neubauer "Endothelin-1 Increases Susceptibility of Isolated Rat Hearts to Ischemia/ Reperfusion Injury by Reducing Coronary Flow" J Mol Cell Cardiol 30: 2657-2668 (1998)
  • K-H. Hiller, M. Bock, C.M. Wacker, L.R. Schad, C. Waller, A. Haase, G. van Kaick, G. Ertl, W.R. Bauer "MR-perfusion measurements: Basic methodology and current status" MAGMA 6: 98-99 (1998)
  • B. Illing, M. Horn, B. Urban, H. Strömer, K. Schnackerz, M. de Groot, A. Haase, K. Hu, G. Ertl, S. Neubauer "Changes of Myocardial High-Energy Phosphates with the Cardiac Cycle During Acute or Chronic Myocardial Stress" Magn Reson Med 40: 727-732 (1998)
  • E. Kahler, C. Waller, E. Rommel, K.H. Hiller, S. Voll, A. Broich, K. Hu, D. Schnackerz, W. R. Bauer, G. Ertl, A. Haase "Quantitative Regional Blood Volume Studies in Rat Myocardium in Vivo" Mag Res Med 40: 517-525 (1998)
  • M. v. Kienlin, C. Rösch, Y. Le Fur, W. Behr, F. Roder, A. Haase, M. Horn, B. Illing, K. Hu, G. Ertl, S. Neubauer "Three-Dimensional 31P Magnetic Resonance Spectroscopic Imaging of Regional High-Energy Phosphate Metabolism in Injured Rat Heart" Magn Res Med 39: 731-741 (1998)
  • J. Ruff, F. Wiesmann, K.-H. Hiller, S. Voll, M. von Kienlin, W.R. Bauer, E. Rommel, S. Neubauer, A. Haase "Magnetic Resonance Microimaging for Noninvasive Quantification of Myocardial Function and Mass in the Mouse" Magnet Res Med 40: 43-48 (1998)
 1997
  • A. Bauer, G. Becker, P. Henz, P. Jachimczak, K.Q. Schwarz, A. Haase, U. Bogdahn "Transcranial duplex ultrasound: experience with contrast enhancing agents" Int Angiol 16: 216-221 (1997)
  • W.R. Bauer, F. Roder, K.-H. Hiller, H. Han, S. Fröhlich, E. Rommel, A. Haase, G. Ertl "The Effect of Perfusion T1 after Slice-Selective Spin Inversion in the Isolated Cardioplegic Rat Heart: Measurement of a Lower Bound of Intracapillary-Extravascular Water Proton Exchange Rate" Mag Res Med 38: 917-923 (1997)
  • K.-H. Hiller, F. Roder, P. Adami, S. Voll, P. Kowallik, A. Haase, G. Ertl, W.R. Bauer "Study of Microcirculation by Coloured Microspheres and NMR-microscopy in Isolated Rat Heart: Effect of Ischaemia, Endothelin-1 and Endothelin-1 Antagonist BQ 610" J Mol Cell Cardiol 29: 3115-3122 (1997)
  • F. Roder, K.-H. Hiller, P. Henz, M. Von Kienlin, W.R. Bauer, A. Haase "Three Dimensional Coronary Angiography of the Perfused Rat Heart" Magn Reson Imag 7(2): 316-320 (1997)
 1996
  • W. R. Bauer, K.-H. Hiller, F. Roder, E. Rommel, G. Ertl, A. Haase "Magnetization Exchange in Capillaries by Microcirculation Affects Diffusion-Controlled Spin-Relaxation: A Model Which Describes the Effect of Perfusion on Relaxation Enhancement by Intravascular Contrast Agents" Mag Res Med 35: 43-55 (1996)
  • G. Ertl, K. Hu, W.R. Bauer, B. Bauer "The renin angiotensin system and coronary vasomotion" Heart (Suppl 3): 45-52 (1996)
  • K.-H. Hiller, P. Adami, S. Voll, F. Roder, P. Kowallik, W.R. Bauer, A. Haase, G. Ertl "In vivo Colored Microspheres in the Isolated Rat Heart for Use in NMR" J Mol Cell Cardiol 28: 571-577 (1996)
 1995
  • W. R. Bauer, K.-H. Hiller, F. Roder, S. Neubauer, A. Fuchs, C. Große Boes, R. Lutz, P. Gaudron, K. Hu, A. Haase, G. Ertl "Investigation of Coronary Vessels in Microscopic Dimensions by Two- and Three-dimensional NMR Microscopic Imaging in the Isolated Rat Heart" Circulation 92: 968-977 (1995)
  • W. Peters, H. Hopp, W.R. Bauer, P. Kowallik, M. Meesmann "Eine ungewöhnliche Serie von Komplikationen bei der Therapie mittels implantierbarem Kardioverter-Defibrillator" Z Kardiol 84: 296-300 (1995)
 1994
  • W.R. Bauer, S. Neubauer, G. Obitz, G. Ertl "Interrelation of atrial natriuretic peptide and the renin-angiotensin system in the isolated perfused rat heart" J Mol Cell Cardiol 26: 527-537 (1994)
  • W.R. Bauer, K.H. Hiller, F. Roder, A. Haase, G. Ertl "Variable Response of coronary restistance and conductance Vessels to Endothelin-1. A NMR-Microscopy Study in the isolated Rat-heart" Circulation 90: 630-630 (1994)
 1993
  • M. Meesmann, J. Boese, D.R. Chialvo, P. Kowallik, W.R. Bauer, W. Peters, F. Grüneis, K.D. Kniffki "Demonstration of 1/f fluctuations and white noise in the human heart rate by the variance time curve: implications for self-similarity" Fractals 3 (1): 312-320 (1993)